FLASH Therapy QA Tools

In recent years, there have been many studies on the benefits of delivering a radiation dose to a tumor with a very high dose rate of at least 40 Gy/s (FLASH), see e.g. [1], [2]. Currently, a lot of research & development effort is focused on moving on from these studies to routinely available clinical treatments using electron and proton radiation.

[1] J.D. Wilson et al, Front Oncol 2020 Jan 17;9:1563
[2] J.R. Hughes and J.L. Parsons, Int J Mol Sci 2020 Sep 5;21(18):6492

FLASH: Revolution in RadiationTherapy

FLASH is a new, promising approach in radiationtherapy. In FLASH therapy an ultra-high dose rate is applied in less than one second. FLASH radiations place special demands on dosimetric measurement technology. 3 questions and 3 answers to Dr. Rafael Kranzer, R&D Project Manager, and Dr. Frank Schwamm, Product Manager, who develop FLASH dosimetry solutions at PTW.

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Products available for research use in proton and electron FLASH radiotherapy dosimetry

flashDiamond Detector T60025

Detector for electron FLASH dosimetry

UNIDOS Tango Reference Class Electrometer

UNIDOS Tango and UNIDOS Romeo Reference Class Electrometers

The New Generation of Reference Class Electrometers

Advanced Markus Electron Chamber

Plane parallel ion chamber for high-energy electron measurements

microDiamond

Synthetic Diamond Detector for High-Precision Dosimetry

OCTAVIUS Detector 1600XDR

Patient Plan Verification and Quality Assurance for Proton and Heavy Ion beams

RUBY Modular QA Phantoms

Modular QA phantom

BEAMSCAN

3D Water Scanning System with Wireless Auto Setup and Operation

MP3-P/PL

Hi-Tech 3D Water Phantom Solution for Particle Therapy Treatment Machines

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Brochure

FLASH QA Tools ( )

Selected Publications

The European Joint Research Project UHDpulse–Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates (A Schüller, S Heinrich, C Fouillade, A Subiel, L De Marzi, F Romano, ...) Physica Medica 80, 134-150

FLASHflashDiamond

Ion collection efficiency of ionization chambers in ultra‐high dose‐per‐pulse electron beams (R Kranzer, D Poppinga, J Weidner, A Schüller, T Hackel, HK Looe, ...) Medical physics 48 (2), 819-830

FLASHflashDiamond

Development of an ultra‐thin parallel plate ionization chamber for dosimetry in FLASH radiotherapy (F Gómez, DM Gonzalez‐Castaño, NG Fernández, J Pardo‐Montero, ...) Medical Physics 49 (7), 4705-4714

FLASHflashDiamond

VHEE beam dosimetry at CERN Linear Electron Accelerator for Research under ultra-high dose rate conditions (D Poppinga, R Kranzer, W Farabolini, A Gilardi, R Corsini, V Wyrwoll, ...) Biomedical Physics & Engineering Express 7 (1), 015012

FLASHflashDiamond

Charge collection efficiency, underlying recombination mechanisms, and the role of electrode distance of vented ionization chambers under ultra-high dose-per-pulse conditions (R Kranzer, A Schüller, FG Rodríguez, ...) Physica Medica 104, 10-17

FLASHflashDiamond

Calorimeter for real-time dosimetry of pulsed ultra-high dose rate electron beams (A Bourgouin, A Schüller, T Hackel, R Kranzer, D Poppinga, RP Kapsch, ...) Frontiers in Physics 8, 567340

FLASHflashDiamond

Absorbed-dose-to-water measurement using alanine in ultra-high-pulse-dose-rate electron beams (A Bourgouin, T Hackel, M Marinelli, R Kranzer, A Schüller, RP Kapsch) Physics in Medicine & Biology 67 (20), 205011

FLASHflashDiamond

Development and benchmarking of a dose rate engine for raster‐scanned FLASH helium ions (L Rank, O Dogan, B Kopp, S Mein, G Verona‐Rinati, R Kranzer, ...) Medical Physics 51 (3), 2251-2262

FLASHflashDiamond

State-of-the-art silicon carbide diode dosimeters for ultra-high dose-per-pulse radiation at FLASH radiotherapy (C Fleta, G Pellegrini, P Godignon, FG Rodríguez, J Paz-Martín, R Kranzer, ...) Physics in Medicine & Biology 69 (9), 095013

FLASHflashDiamond

Designing an ultra-thin parallel-plate ionization chamber for ultra-high dose rate applications (FG Rodríguez, JP Martín, DM Gonzalez-Castaño, NG Fernández, ...) Physica Medica: European Journal of Medical Physics 104, S104-S105

FLASHflashDiamond

Development of improved dosimetry standards for FLASH radiotherapy: the UHDpulse Project (A Cimmino, A Schüller, S Heinrich, C Fouillade, A Subiel, L De Marzi, ...) 14th International Conference on Radiation Shielding and 21st Topical …

FLASHflashDiamond

Recent developments in absolute dosimetry for FLASH radiotherapy. (Subiel, A. & Romano, F.) Br. J. Radiol. 96, (2023).

FLASHflashDiamond

Ultra-high dose rate dosimetry: Challenges and opportunities for FLASH radiation therapy. (Romano, F.et al) Medical Physics 49, 4912–4932 (2022).

FLASHflashDiamond

High dose-per-pulse electron beam dosimetry - A model to correct for the ion recombination in the Advanced Markus ionization chamber. (Petersson, K. et al.) Med. Phys. 44, 1157–1167 (2017).

FLASHflashDiamond

Commissioning of an ultra‐high dose rate pulsed electron beam medical LINAC for FLASH RT preclinical animal experiments and future clinical human protocols. (Moeckli, R. et al.) Med. Phys. 48, 3134–3142 (2021).

FLASHflashDiamond